The Introduction of Venom: May 1988. The Amazing Spiderman #300 marks the first full appearance of Venom, one of Spider-Man's most iconic and enduring villains. Venom is the result of Eddie Brock bonding with the alien symbiote that Spider-Man once wore as a costume. Venom possesses similar powers to Spider-Man, including enhanced strength, agility, and the ability to produce web-like substance.